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In this study, we searched papers published in English and Chinese via PubMed, Embase, Scopus, and Web of Science database, intending to provide an overview of current knowledge relevant to the pathogenesis and susceptibility genes to NIHL

For instance, in CKD rats, drinking HRW significantly reduced plasma Monocyte Chemoattractant Protein1 (MCP1) levels [247]

Bile salt export pumps (BSEP, ABCB11) is another member of the Mdr family

While GSH depletion is detrimental for cell and organismal viability, excess GSH can also cause reductive stress and lethally disrupt iron metabolism

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Several studies showed that different GHSR signaling pathways regulate distinct physiological functions 25,26,27