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Therefore, it is recommended to focus on a titrated approach to find the optimum NA supplementation without promoting excessive NAD + catabolism metabolite generation

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A possible mechanism at a neuronal level could be that stimulation of mu-opioid receptors suppresses interneuron spiking and increases glutamate-coded output of prefrontal neurons at multiple projection targets, which in turn might engender disorganized control and decision processes (Baldo, 2016)

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