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In INS1 cells, lipotoxicity does not exert an effect on its own but requires high glucose (11 and 25 mM) to increase triglyceride accumulation, proton leak, and MMP (Oberhauser et al., 2020)

For adjuvant treatment with radiotherapy: Administer after radiotherapy, the standard dose is 1.5 grams per square meter of body surface area, and the specific details shall be followed by the doctor

SERMs are non-steroidal estradiol analogs with mixed agonist-antagonist effects on ERs and are used in osteoporosis and breast cancer treatment (Girase et al., 2023)

doi: 10.1016/j.diabres.2021.109119 3

All p- values were corrected via the Benjamini-Hochberg step-up procedure for false discovery rate (FDR) correction