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Heliyon 10 , e32004 (2024)

Elevated levels of sFASL have been observed in patients with MASLD, and this increase is thought to reflect enhanced apoptotic activity in hepatocytes

Extracts of HeLa WT , HeLa BAG3 KO or HeLa G6PD KO cells were immunoblotted with the indicated antibodies (bottom)

Acknowledgments Expressing gratitude to all those who have contributed to the completion of this research

For instance, excessive iron promotes the Fenton reaction, generating more ROS, which further damages melanocytes (54)

Of note, here and in contrast to previously mentioned studies, the anti-cancer activity of vitamin C was due to reduced intracellular ROS levels, which induced the translocation of Ras from the plasma membrane into the cytosol and the inhibition of the Ras/MEK/Erk signaling pathway