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In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

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Certain medications can help, including birth control and other hormonal treatments, but these also have systemic effects on the body

GraphPad Prism 8.0 was utilized to analyze the results, estimate bias, and compare the analytical methods