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Compared to the sham group, DMM-operated joints exhibited severe articular surface erosion, fissured cartilage layers and proteoglycan depletion, as evidenced by diminished SO-FG staining intensity

114 Prolonged exposure to alcohol leads to the release of oxidized mitochondrial DNA via extracellular vesicles in ALDH2-deficient mouse liver cells, and this DNA is transferred to nearby HCC cells and activates carcinogenic (JNK, STAT3, BCL2, and transcriptional coactivator with PDZ-binding motif) pathways, promoting the development of alcohol-related HCC

[DOI] [PMC free article] [PubMed] [Google Scholar] 306.Prabhudesai S., Sinha S., Attar A., Kotagiri A., Fitzmaurice A.G., Lakshmanan R., Ivanova M.I., Loo J.A., Klarner F.G., Schrader T., et al

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The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production

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