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Hypoxic-reoxygenated mice were fed normoxic for 28 days after receiving chronic hypoxia

doi: 10.1038/s41380-022-01436-7 40 CahoyJ

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While our recent studies demonstrated that the loss of AGXT exacerbates diet-induced MASH in mice 12 , the hepatic regulation of oxalate metabolism and its levels in humans and mice with MASH, the effects of oxalate accumulation in hepatocytes, the primary cells responsible for its formation and the therapeutic potential of targeting impaired oxalate metabolism in MASH, have not been systematically studied

The major intracellular ferrireductase is identified as STEAP3 (six-transmembrane epithelial antigen of prostate protein family, member 3)

Subcutaneous apomorphine infusion Apomorphine is a dopamine agonist with affinity for various dopamine receptor subtypes, characterized by rapid absorption and a short half-life