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Competitive experiments revealed that the addition of urea significantly weakened the drug effect, confirming that the targeting molecule was indeed UreI and providing direct evidence for drug-channel lock-and-key delivery

10.1016/j.stem.2008.01.014 26 InoueM

doi:10.1111/joim.13279

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Further studies demonstrated that BHB induced -hydroxybutyrylation of histone H3 at lysine 9 (H3K9bhb) and upregulated matrix metalloproteinase-2 (MMP-2) expression [10]

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