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Whether Dihexa sees renewed academic interest depends on funding and corporate interest, neither of which appears strong as of 2025

This might be seen as a network of evidence for the physiologic significance of the revealed BPC 157/NO-system interplay (i.e., BPC 157 was found in in situ hybridization and immunostaining studies in humans to be largely distributed in tissues [20] and may have additional physiologic regulatory roles [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40])

BPC-157, in animal models, works better for deeper musculoskeletal injuries (tendons, ligaments, muscle) while GHK-Cu is excellent for skin and dermal matrix remodeling

Images were obtained from all tissue sections at both stump-callus interfaces and in mid callus, at the right, center and left side, of each staining (collagen 1, collagen 3 and elastin) with magnifications of 10x/0.30, 25x/0.95 (water) and 63x/1.20 (water) (Supp Fig