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Trimethylamine N-oxide and cardiovascular events in hemodialysis patients

Pooled analyses of 199 placebo-controlled clinical trials (mono- and adjunctive therapy) of 11 different AEDs showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo

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But vegans and others with metabolic disorders may not be able to either obtain or produce enough