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From a health economics perspective, lifelong B12 supplementation should involve cost-effective delivery routes and tailored dosages to optimise clinical outcomes while minimising excess

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In a cohort of pregnant women in Bangalore, India, with a high incidence of vitamin B-12 deficiency, we reported previously that women in the lowest tertile for plasma vitamin B-12 concentration during all 3 trimesters of pregnancy had significantly higher risk of IUGR that persisted after adjusting for maternal age, weight, education, and parity (12)