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Getting the dose exactly right at this phase matters because it establishes your baseline response before deciding whether to increase further
Cherrier, Amory, Ersek, Risler, & Shen, 2009)

No increase in the frequency or severity of adverse reactions or decrease in efficacy was seen with an increased dose or duration

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For BDNF optimization specifically, several stacking strategies have theoretical and preliminary experimental support

the four mechanisms behind it (neuroinflammation, fuel, hormones and BDNF plasticity), with the 2024 Nature Neuroscience bloodbrain-barrier evidence and the Gladstone fibrin research
