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Administer an initial dose of 500 mg/m, dissolved in 100 ml of normal saline, via intravenous administration, followed by a maintenance dose of 300600 mg daily via intramuscular injection

This was paralleled by increased expression of ROS-sensitive transcriptional regulators of insulin sensitivity and ROS defense capacity, peroxisome proliferator-activated receptor (PPAR) and PPAR coactivators PGC-1 and PGC-1 only in the absence of antioxidants

doi: 10.1083/jcb.110.2.327

The process of drug metabolism is also called biotransformation

As a control, we performed the same experiment by feeding the neurons with the methionine analog azidohomoalanine (AHA), which incorporates into de novo synthesized proteins and is then similarly tagged using click chemistry 40 , and we found little colocalization between TNR and AHA (Fig