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In turn, this exacerbates the increased glucose output from the liver associated with insulin resistance and induces production of kisspeptin1 in hepatocytes that can further impair -cell insulin secretion (132)

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131 Nevertheless, most of the evidence gathered to date was derived from smaller mechanistic studies, and the few large randomized controlled trials have not shown a significant mortality benefit of using these agents

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Free radicals are unstable molecules that can damage cells and contribute to aging and various diseases