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Fatigue in multiple sclerosis: A review of the exploratory and therapeutic potential of noninvasive brain stimulation

doi: 10.1016/j.jddst.2020.101581 [DOI] [Google Scholar] 152.Pires PC, Rodrigues M, Alves G, Santos AO

However, these results were insufficient to confirm the stability of ligandprotein binding and subsequent enzyme activation because docking deals with proteins as rigid molecules and ignore time evolution in ligandprotein interaction

In a later study in 12-month-old APP/PS1 mice (i.e., advanced stages of AD), 1:1 CBD:THC combination extract was still effective in reversing the memory deficit in the two-object recognition task of these older AD mice (no effects on non-AD transgenic control mice), but unable to alter amyloid pathology or gliosis at this later age (Figure 1 for a summary of CBD+THC effects in AD