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Mass Spectrometric Screening of Solvent Extractables from Strain F3876/87 Bacterial pellets, prepared from F3876/87 liquid cultures (100 mL) by centrifugation, were extracted with 10 mL of MeOH, MeCN, or MeCN/H 2 O (70/30, v/v), respectively, by shaking overnight (15 h) at room temperature

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Journal of Peptide Research

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Mechanistically, DOX stabilizes the copper importer SLC31A1 (CTR1) by inhibiting its proteasomal degradation and downregulating the copper efflux transporter ATPase Copper Transporting Beta (ATP7B), leading to a net increase in cellular copper [17, 76]