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Specifically, the activity of the rate-limiting enzyme for GSH biosynthesis (i.e., -glutamylcysteine synthase) is increased in exercise-trained muscles and probably plays an important role in exercise-induced increases in GSH synthesis in skeletal muscle (221, 246, 352)

An allograft is usually used when cartilage defect being treated is too large for an autograft (2cm)

Further enzymatic investigation showed that the wild-type enzyme exhibited a robust DTNB reductase activity, and SjTGR U597C with a mutation on the critical selenol group had no detectable redox catalytic activity under the same assay conditions (Fig 1L), demonstrating that the selenol group is essential for SjTGR enzymatic function