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ARA 290, a Nonerythropoietic Peptide Engineered from Erythropoietin, Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes

Kazemzadeh S, Mohammadpour S, Madadi S, Babakhani A, Shabani M, Khanehzad M

They exert their effects either directly by stimulating goblet cell-stimulated mucus secretion such as mucin 2 (MUC2) secretion in colonic epithelial cells that enhances intestinal barrier function and immune response

Key benefits for perimenopausal women: Supports restoration of natural GH pulses that diminish alongside estrogen decline, helping offset fatigue, reduced muscle tone, and metabolic slowdown common in perimenopause Promotes deeper slow-wave sleep by amplifying nighttime GH secretion, addressing the sleep disruption that affects an estimated 40-60% of women during the menopausal transition, per Tyde Wellness Associated with improved body composition including reductions in visceral abdominal fat and increases in lean muscle mass

[DOI] [PubMed] [Google Scholar] 36.Schramm D.D., Karim M., Schrader H.R., Holt R.R., Kirkpatrick N.J., Polagruto J.A., Ensunsa J.L., Schmitz H.H., Keen C.L

This is partly due to the contraindication of aspirin in pediatric patients (Reye syndrome)