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In the liver, feeding-induced FXR activation elevates SHP expression, which forms a complex with CREB to recruit lysine-specific demethylase 1 (LSD1) to the promoters of ATGs such as Tfeb, Ulk1 , and Atg7
Mitochondrial Signalling (MOTS-c) MOTS-c is a mitochondrial-derived peptide that modulates AMPK signalling and the cell's metabolic stress response

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However, under pathological conditions, mitochondrial dysfunction and protein aggregation (e.g., A, -synuclein) engage in a mutually reinforcing vicious cycle, distinct from a unidirectional causal relationship
