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Iron was shown to drive ferroptosis through Fenton chemistry [5], where ferrous iron (Fe 2+ ) reacts with hydrogen peroxide (H 2 O 2 ) to generate hydroxyl radicals (HO ) that initiate and amplify lipid peroxidation (Fig

These factors disrupt insulin receptor signaling and downstream effectors across multiple organs, including muscle, heart, kidney, and pancreas

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Interestingly, all other tested pathways (oxidative stress, DNA damage, and inflammatory stress) were not significantly activated by either AQ-QI or DEAQ-QI treatment (Supplementary Figure S5)

It achieves this by blocking the tyrosinase enzyme, which is necessary for the synthesis of melanin
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