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AOD9604 for Cartilage Repair in Osteoarthritis: Preclinical Efficacy and Mechanisms [J]

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The genes for mitobiogenesis and mitophagy were downregulated when both Mfn1 and Mfn2 were removed in midgestational and postnatal cardiac myocytes, and the mice went on to develop cardiomyopathy and died within 16 days of birth [244]

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