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Biochim Biophys Acta, Gen Subj 1760:17891793

However, whether ALOX is a key mediator of lipid peroxidation induced by GPX4 deficiency is debated [20,27]

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This discrepancy implies that additional layers of regulation, including altered translational efficiency and/or increased protein turnover, probably further contribute to cholesterolinduced PPAR downregulation, representing compelling areas for future investigation

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As the aforementioned factors have been previously described in excellent articles [95, 96], we will not discuss them here (Fig