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Phase I Transformation Breakdown of toxins Phase I enzymes mainly the cytochrome P450 (CYP) family break down toxic substances through oxidation, reduction and hydrolysis reactions

JA, its methyl ester (MeJA), and its isoleucine conjugate (JA-Ile) are fatty acid derivatives known together as jasmonates (JAs)

Schisandrin C targets Keap1 and attenuates oxidative stress by activating Nrf2 pathway in Ang II-challenged vascular endothelium

Fujita K, Matsuo N, Mori O, Koda N, Mukai E, Okabe Y, Shirakawa N, Tamai S, Itagane Y, Hibi I

Finally, tissue recombination models are another model type, where benign or malignant epithelial cells combined with mesenchymal cells, are implanted subcutaneously or under the renal capsule in immunocompromised host mice [76]

10.1038/s41419-021-03790-w 69 LuoX