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However, how this happens is not completely understood

For B12 deficiency, a typical injection dose is 1,000 mcg once a week for 4 to 8 weeks and then 1,000 mcg once a month

Supplementation with B12 and folate may also help to reduce homocysteine, which is linked to high uric acid levels

Signs to watch for include: Unexplained fatigue Persistent nausea, vomiting, or diarrhea Loss of appetite Unintended weight loss Yellowish skin Sore mouth or tongue Depression or irritability Behavioral changes Numbness and tingling sensations in the hands and feet Vision changes Mental confusion Should You Consider a B12 Shot

Also, plunging syringe too fast can hurt