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However, inflammation is not inherently detrimentalit also plays a critical role in liver repair and antimicrobial defense, particularly against bacterial infections

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In this scenario, it becomes very attractive to study and explore the endothelium, through which inflammatory cells must transmigrate [transendothelial migration (TEM)] to reach the lung parenchyma and cause damage ultimately leading to COPD onset and progression

29 , 30 , 150 In contrast, polymeric/lipid systems more often co-deliver ferroptosis enablers or sensitise antioxidant checkpoints

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