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These include asbestos (renal adenocarcinoma), analgesic abuse (transitional carcinomas), and lifestyle factors (tobacco use, alcohol, coffee)

Transferrin receptor 1 (TfR1), a well-known regulator of cellular iron that internalizes the transferrin-bound iron, plays a significant role in ferroptosis, and ROS induction has been shown to enhance TfR1 protein levels and serves as a marker of ferroptosis 8

AHK-Cu, or Alanine-Histidine-Lysine-Copper, is a naturally occurring tripeptide complexed with copper that has been investigated for its role in activating copper-dependent enzymatic processes and modulating extracellular matrix proteins involved in tissue structure and repair