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Description
An A-ring derivative, 4-halo-(-)-colchicine shows strong activity against human cancer cells, including lung adenocarcinoma A549, colon adenocarcinoma HT29, and HCT116, with the high selectivity and the low toxicity 205
The effect was abolished in PepT1-knockout mice, confirming the transport pathway (PMC4957955)
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doi: 10.1021/tx500210e 18 GetzE
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