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This helps cancer cells take up more glutamine and supports the metabolic demands of cancer cells, thereby promoting glutamine uptake and metabolism by tumor cells and supporting the rapid proliferation and growth of tumor cells (Fig

The mevalonate pathway (MEP) is a metabolic pathway that uses acetyl-coA as a raw material to synthesize isoprene pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which play an important role in regulating cell growth, differentiation, and proliferation

This study was supported by the National Natural Science Foundation of China (82274194), the Jiangsu Natural Science Funds (BK20211224), CAMS Innovation Fund for Medical Sciences (CIFMS 2021-I2M-5-011), and the Natural Science Foundation of Hebei Province (H2020208025, H2021208006, H2021302001, C2021418001), Leading technology foundation research project of Jiangsu province (BK20192005)