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This is because some sporadic tumours show MSI without an underlying germline mutation (i.e
Cognitive behavioral therapy and clinical applications

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Alber J., Alladi S., Bae H., Barton D.A., Beckett L.A., Bell J.M., Berman S.E., Biessels G.J., Black S.E., Bos I., et al

GSNOR C47S and GSNOR C177S showed drastically reduced specific activity (100-fold less and 50-fold less, respectively) compared to WT GSNOR ( Figure 6D ) demonstrating the importance of these two cysteines

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