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Conversely to the use of inhibitors, due to the interest in promoting maintenance of NAD + levels in aging and age-associated conditions, the development of NAMPT activators has been the emphasis of recent investigation

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To induce overexpression of LOXL2 or LOXL2-DM, cells were transduced with adenovirus (100 MOI for both AdLOXL2 and AdLOXL2-DM) for 24 h before initiating the activity assay

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Inhibition of IGF-1R reduces the sensitivity of cells to tamoxifen, which may be due to the inhibition of FoxO1 expression by the reduction of IGF-1R expression (Zhang et al., 2018)