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These mitochondrial impairments not only compromise energy production but also act as pro-inflammatory stimuli, promoting chronic neuroinflammation through dysregulated mitochondrial signaling and innate immune response

Neurology 35:16601662

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They observed, following L-carnitine supplementation (3 g/day for 3 weeks) in healthy untrained men, a reduction in circulating CK and DOMS compared to placebo

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Feedforward inhibition, which depends on reliable interneuron spiking, is essential for sharpening the temporal window of excitation and ensuring coherent integration of sensory inputs into motor circuits