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Immune cells, such as macrophages and neutrophils, can also generate ROS due to their oxygen-dependent mechanisms to fight against invading microorganisms based on NOX2 isoform ( ROS are produced in mitochondria during aerobic metabolism (Rodriguez and Redman, 2005)

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120 Additionally, FGF21 secreted by breast cancer cells can alter cholesterol metabolism in CD8+ T cells, causing excessive cholesterol biosynthesis and inducing CD8+ T-cell exhaustion

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