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In cells, H 2 O 2 is produced from various sources such as either a spontaneous or catalytic breakdown of superoxide anion, produced through the partial reduction of oxygen during aerobic respiration or through various oxidases, and is quickly converted into H 2 O 2 by superoxide dismutase present in the mitochondria or cytosol or in the extracellular space [45,46,47] and regulatory machinery of the cell maintains the concentration in different sub-cellular compartments

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Because muscles generate a steady supply of ammonia when breaking down amino acids during exercise, they are uniquely suited to house this pool

J Biol Chem 293:1827018284

Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine

According to the Cochrane review guidelines (13), if severe heterogeneity was present at P 50%, the random-effects model was chosen