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Author contributions This study was conceived and designed by ET, who wrote the initial draft

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TGF- also accounts for phenotypic changes of fibroblasts into -smooth muscle actin (-SMA)-positive MFBs (contractile cells regulating wound contraction and fibrosis) ( 3.3 Angiogenesis biphasic pattern The biphasic pattern of angiogenesis is another crucial hallmark of OSF

A 400 L aliquot of 4% RBCs was mixed with 400 L of SeMSN or RBC@SeMSN@Uri at various concentrations (12.5, 25, 50, 100, and 200 gmL 1 ) and incubated at 37C for 24 h