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The data generated during this phase help define the dose range that may be explored in subsequent studies and contribute to understanding exposure-response relationships, pharmacokinetic behavior and safety considerations associated with the investigational compound

We aim to make batch-level documentation available whenever possible

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There is a crucial direction for future research to include such a group, with the necessary ethical approvals, to further elucidate the interplay between diabetes, CVD, and the investigated biomarkers

Recent research focuses on the heterologous expression of FTases from yeast and bacterial expression systems [57]

[DOI] [PMC free article] [PubMed] [Google Scholar] 131.Ohishi T., Goto S., Monira P., Isemura M., Nakamura Y