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Metal-Mediated Bridging Strategies Natural cyclic peptides, exemplified by valinomycin and various potent ionophores with metal-mediated side-chain links within their structures, have inspired scientists to leverage metals to enclose macrocycle peptides

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Erner 2003)

doi: 10.1016/j.lwt.2019.02.002

As major detoxifying enzymes, they can detoxify and metabolize exogenous toxic substances, and inactivate the endogenous , -unsaturated aldehydes, quinones, epoxides and the hydroperoxides produced during antioxidant or oxidative stress

CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data