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In contrast, three proteins decreased collectively and significantly by at least 0.67-fold in OA-treated cells (Figure 1D), while the abundance of another protein (GSTA1) was further reduced on the fifth day of treatment (0.89-fold and 0.39-fold, respectively, compared to the control)

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Because the brain consumes roughly 20% of the body's total energy and is highly susceptible to lipid peroxidation, this lack of antioxidant protection directly contributes to neuroinflammation, cognitive dysfunction, and the debilitating "brain fog" characteristic of these conditions

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In the SLC7A11 systemic knockout mouse model, depletion of GSH levels was observed, but did not cause spontaneous hepatic iron deficiency, but rather increased sensitivity to ferroptosis [52]

Neurodegenerative diseases, including Alzheimers and Parkinsons, are associated with abnormal neural synchronization [543], and numerous publications report impaired gamma oscillations in schizophrenic patients in a variety of behavioral tasks [542, 544]