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The fumarate component participates in the citric acid cycle as an intermediate metabolite, potentially supporting aerobic energy production and cellular respiration processes

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and this appears to be a result of the disease itself, not of decreased dietary intake of vitamin C (Sinclair 1994)

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The presence of centrilobular DR may predict the progression of liver fibrosis in patients with NASH [107]

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Pharmacol Res 119:303312

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365 These nanovesicles deliver bioactive molecules, including proteins, lipids, and nucleic acids, to mediate intercellular communication and modulate recipient cell behavior

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10.1002/jhbp.830 54 Hamilton-ReevesJ

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