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Protocol sequencing The sequence is critical

22 However, iron overload can be induced after repeated transfusions for SCD treatment, 22 which leads to an elevated iron load in up to 70% of patients

In intervention studies, appropriate methodology includes the use of well-matched control groups, pre- and post-treatment testing, representative samples, sufficient sample sizes, random assignment, and procedures to eliminate bias

Those taking certain medications that affect how you absorb vitamin B12

One such combination therapy is currently being evaluated in clinical trials and is discussed later in this article