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Paeoniflorin promotes intestinal stem cell-mediated epithelial regeneration and repair via PI3K-AKT-mTOR signalling in ulcerative colitis

Pro-resolving lipid mediators (PRLMs), including resolvins, maresins, protectins, and lipoxins, represent a distinct class of bioactive metabolites derived from polyunsaturated fatty acids

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Nitric oxide (NO) and RNIs such as peroxynitrite have a damaging effect on mycobacteria (Long et al., 2005

NS Non-significant, ** Significant, NE Not evaluated, EO Essential oil, OA Organic acid, VH Villi height, CD Crypt depth, D Duodenum, J Jejunum, IL Ileum For example, diets enriched with spent tea leaves and mannan-oligosaccharides increased the duodenal VH/CD ratio, likely due to the hydrolysis of oligosaccharides into SCFAs which serve as energy sources for enterocytes [190]

C-2 fluorination ( 5 ) of the parent sulfonyl compound enhanced reactivity while the introduction of a 7-amino group ( 6 ) decreased reaction rate