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10.1016/j.sleep.2021.08.003

doi: 10.1016/j.brainres.2010.12.014 162

Paracetamol metabolism and related genetic differences

You would never know by looking at it, because the solution might still appear clear, but the biological activity would be degraded

For neuroprotective mitochondria-targeted drugs with several systemic side effects, such as pitavastatin and pentoxifylline, intranasal drug administration could be a promising option to target the CNS using a lower dose that would minimize systemic exposure, thus decreasing the unwanted adverse systemic effects
