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In animal studies, this build-up has been associated with decreased semen quality, most likely due to inflammation and oxidative stress-induced damage

doi: 10.1016/j.abb.2021.108775

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The The CIR (Cosmetic Ingredient Review) Expert Panel concluded Kojic Acid is safe for use in cosmetic products at concentrations up to 1% and the EU's SCCS (Scientific Committee on Consumer Safety) considers it safe as a skin lightening agent at concentrations up to 0.7%