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Valproate-induced hyperammonaemic encephalopathy In chronic VPA dosing hyperammonaemia occurs in nearly 50% of patients, but this remains asymptomatic in almost 50% of cases [39]

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35 Common doses are 5 to 15 mg of bisacodyl orally per day or 10 mg suppository rectally per day and 1 to 2 tablets of senna orally twice daily

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