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Relevance of Experimental Doses to Human Exposure A major challenge in interpreting the toxicological evidence on MNPs is the disconnect between the high, often acute, concentrations used in experimental models and the lower, chronic exposures experienced by humans in real-world settings

, & Ahmad, G

D., Bao W., Faden A

FGF2-dependent neovascularization of subcutaneous Matrigel plugs is initiated by bone marrow-derived pericytes and macrophages

After 24 hrs, media were removed and cells incubated with a staining solution of mitotracker green (50 nM) at 37 C

The following parameters were used for calculations: liver blood flow 1.32 L/h/kg (human), 5.4 L/h/kg (mouse)