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Consequently, SOD2 activity is approximately 40% higher following the mitochondrial import in the SOD2 Ala precursor compared to its Val counterpart ( SOD2 rs4880 polymorphism is believed to be associated with the susceptibility to various diseases, including cancer, neurodegenerative disorders, chronic kidney disease (CKD), and cardiovascular diseases ( The SOD3 gene encodes for superoxide dismutase three playing a pivotal role as an extracellular antioxidant enzyme

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Antioxidants are needed in the body to protect cell integrity and to fight free radical and oxidative damage

K.KumarR.MathurM.UpadhyayT

2003 Jan;11(1):23-9