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Hemoglobinopathies Sickle cell disease SCD is caused by a point mutation in the Hb subunit chain and shows multiple clinical manifestations and early mortality, particularly if the individual is homozygous for the mutation or untreated (80)

doi: 10.1016/j.regpep.2012.12.007

Subsequently, HIF-1 influences the expression of numerous genes that are crucial for gastric carcinogenesis

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Another explanation is that there could be a U-shaped association between seminal plasma Se levels and infertility