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How B12 gets into your blood is a complex dance of stomach acids and intrinsic factors that starts with pepsin in the stomach splitting off the B12 from the protein compound

If it takes significantly longer, the powder may have been exposed to moisture or temperature extremes before reconstitution

J., Widjaja, F., Lawton, B., Rosenblatt, A., & Bent, S

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Vitamin B12 in animal products is always bound to protein