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The SURPASS program (for type 2 diabetes) and SURMOUNT program (for obesity) together enrolled over 20,000 participants across multiple Phase III trials

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Based on a comprehensive analysis of the literature, we propose that BACH1 is a typical context-dependent transcription factor, and its function is strongly regulated by the intracellular redox state: ROS levels and heme metabolism significantly influence the expression and activity of BACH1

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