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Description
When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure

Evidence Snapshot (preclinical context) Important: The studies below are primarily animal or in vitro

[DOI] [PMC free article] [PubMed] [Google Scholar] 211.Wang YY, Attane C, Milhas D, Dirat B, Dauvillier S, Guerard A, et al
Taken together, these results suggest that CPP-CAND inhibited the FOXO4-p53 interaction in the nucleus, which enabled the extranuclear transport of p53 and selectively induced apoptosis in senescent cells

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The DOT has not added peptides to its testing requirements
