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Molecular cloning of fatty acid synthase from grass carp (Ctenopharyngodon idella) and the regulation of its expression by dietary fat level

Overall GPX4 was significantly reduced in substantia nigra in Parkinson's vs

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Consistent with decreased fasting glucose levels and improved insulin tolerance observed under chow, and to a lesser extent under HFD conditions (Figure 1, H and I, and Figure 2, J and L), GSH depletion significantly downregulated gluconeogenic enzymes G6pc and Pck1 in chow-fed mice, with no substantial change under HFD (Figure 3, A and B)

Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine

On the other hand, SIRT1 can directly deacetylate c-myc, which destabilizes the c-myc protein and further inhibits SIRT1 expression (44)